Inhibitor bound to cell cycle checkpoint kinase CHK1
The diaryl urea scaffold discovered at ICOS shows the characteristic cis-trans urea conformation directed by the pyrazine on one end and the methoxyl group on the other.
Source: PDB structure 2YWP from Abbott; Bioorg Med Chem Lett. 2006 Apr 15;16(8):2293-8. Image generated by KWF using PyMol (Delano Scientific).